1. Kev Tshawb Nrhiav thiab nthuav dav ntawm Omi Keron mutant strains Thaum Lub Kaum Ib Hlis 9, 2021, South Africa tau kuaj pom tus kabmob B.1.1.529 qhov txawv ntawm tus kabmob tshiab no los ntawm cov qauv kuaj thawj zaug. Tsuas yog 2 lub lis piam, tus kab mob mutant tau dhau los ua qhov tseem ceeb ntawm kev hloov pauv ntawm cov kab mob tshiab tshiab hauv xeev Gauteng, South Africa, thiab nws txoj kev loj hlob sai. Thaum Lub Kaum Ib Hlis 26, WHO tau txhais tias nws yog qhov thib tsib "kev txhawj xeeb ntawm kev txhawj xeeb" (VOC), hu ua Greek tsab ntawv Omicron (Omicron) variant. Raws li lub Kaum Ib Hlis 28, South Africa, Ixayees, Belgium, Ltalis, United Kingdom, Austria, thiab Hong Kong, Tuam Tshoj, tau saib xyuas cov tswv yim ntawm kev hloov pauv. Cov tswv yim ntawm cov kab mob mutant no tsis tau pom nyob rau lwm lub xeev thiab nroog hauv kuv lub tebchaws. Omi Keron mutant tau pom thawj zaug thiab tshaj tawm hauv South Africa, tab sis nws tsis tau txhais hais tias tus kab mob no hloov zuj zus hauv South Africa. Qhov chaw uas tus mutant tau pom tsis yog qhov chaw ntawm keeb kwm.
2. Cov laj thawj muaj peev xwm tshwm sim ntawm Omi Keron mutants Raws li cov ntaub ntawv tam sim no tau qhia los ntawm tus kab mob tshiab tshiab hauv database GISAID, tus naj npawb ntawm cov chaw hloov pauv ntawm tus kab mob tshiab tshiab Omi Keron mutant strain yog ntau dua li ntawm tag nrho cov kab mob tshiab tshiab. Cov kab mob mutant uas tau nthuav dav hauv ob xyoos dhau los, tshwj xeeb tshaj yog nyob rau hauv cov kab mob sib kis (Spike) protein hloov pauv. . Nws tau kwv yees tias cov laj thawj ntawm nws qhov tshwm sim tuaj yeem yog peb qhov xwm txheej hauv qab no: (1) Tom qab tus neeg mob tiv thaiv kab mob tau kis tus kabmob tshiab no, nws tau ntsib lub sijhawm ntev ntawm kev hloov pauv hauv lub cev kom muaj ntau yam kev hloov pauv, uas. kis tau los ntawm caij nyoog; (2) qee cov tsiaj txhu kis tus kabmob tshiab, tus kab mob no tau hloov pauv hloov pauv thaum lub sijhawm kis tus tsiaj, thiab qhov hloov pauv tau siab dua li ntawm tib neeg, thiab tom qab ntawd nchuav rau hauv tib neeg; (3) Cov kab mob sib kis no tau txuas ntxiv mus rau lub sijhawm ntev hauv cov tebchaws lossis thaj chaw uas qhov kev hloov pauv ntawm tus kabmob tshiab genome yog lag luam. , Vim tsis muaj peev xwm saib xyuas tsis txaus, cov kab mob nruab nrab ntawm nws cov evolution tsis tuaj yeem tshawb pom hauv lub sijhawm.
3. Kev sib kis muaj peev xwm ntawm Omi Keron mutant strain Tam sim no, tsis muaj cov ntaub ntawv tshawb fawb txog kev sib kis, kab mob, thiab kev tiv thaiv kev tiv thaiv ntawm Omi Keron mutants hauv ntiaj teb. Txawm li cas los xij, Omi Keron variant kuj tseem muaj qhov tseem ceeb amino acid hloov chaw nyob rau hauv thawj plaub VOC variants Alpha, Beta, Gamma thiab Delta spike proteins, nrog rau kev txhim kho cell receptors. Hloov chaw rau somatic affinity thiab tus kab mob replication muaj peev xwm. Cov ntaub ntawv soj ntsuam kab mob sib kis thiab kuaj pom tau tias cov neeg mob ntawm Omi Keron cov kev hloov pauv hauv South Africa tau nce ntau, thiab tau hloov qee qhov kev hloov pauv ntawm Delta (Delta). Lub peev xwm kis tau tus mob yuav tsum tau saib xyuas thiab kawm ntxiv.
4. Qhov cuam tshuam ntawm Omi Keron qhov sib txawv ntawm cov tshuaj tiv thaiv thiab tshuaj tiv thaiv kab mob Kev tshawb fawb tau pom tias muaj K417N, E484A, lossis N501Y kev hloov pauv hauv S protein ntawm tus kabmob tshiab no qhia tau tias muaj kev tiv thaiv kev tiv thaiv zoo dua; thaum Omi Keron mutant kuj muaj kev hloov pauv peb zaug ntawm "K417N + E484A + N501Y"; Tsis tas li ntawd, Omi Keron mutant kuj tseem muaj ntau lwm yam kev hloov pauv uas yuav txo tau cov kev ua haujlwm tsis zoo ntawm qee cov tshuaj tiv thaiv monoclonal. Lub superposition ntawm kev hloov pauv tuaj yeem txo qhov kev tiv thaiv ntawm qee cov tshuaj tiv thaiv kab mob tiv thaiv Omi Keron mutants, thiab lub peev xwm ntawm cov tshuaj tiv thaiv uas twb muaj lawm los tiv thaiv kev tiv thaiv yuav tsum tau saib xyuas thiab tshawb fawb ntxiv.
5. Puas yog Omi Keron variant cuam tshuam rau nucleic acid nrhiav kom tau cov tshuaj reagents tam sim no siv hauv kuv lub tebchaws? Kev txheeb xyuas genome ntawm Omi Keron mutant strain pom tias nws qhov chaw hloov pauv tsis cuam tshuam rau qhov rhiab heev thiab qhov tshwj xeeb ntawm lub ntsiab nucleic acid nrhiav pom cov tshuaj reagents hauv kuv lub tebchaws. Cov chaw hloov pauv ntawm Omi Keron mutant strain feem ntau yog nyob rau thaj tsam sib txawv heev ntawm S protein gene, thiab tsis nyob hauv cov nucleic acid nrhiav kom tau cov reagent primers thiab soj ntsuam lub hom phiaj cheeb tsam luam tawm nyob rau hauv yim tsab ntawm kuv lub teb chaws "Tshiab Coronavirus Pneumonia. Kev Tiv Thaiv thiab Tswj Kev Pabcuam” (Tuam Tshoj Lub ORF1ab gene thiab N noob tso tawm los ntawm Lub Chaw Tiv Thaiv Kab Mob thiab Tiv Thaiv rau lub ntiaj teb). Txawm li cas los xij, cov ntaub ntawv los ntawm ntau lub chaw soj nstuam hauv South Africa qhia tias nucleic acid kuaj cov tshuaj tiv thaiv uas kuaj pom S gene yuav tsis tuaj yeem kuaj pom S gene ntawm Omi Keron variant.
6. Kev ntsuas los ntawm cov teb chaws thiab cheeb tsam cuam tshuam Raws li kev sib kis sai ntawm Omi Keron mutants hauv South Africa, ntau lub tebchaws thiab cheeb tsam, suav nrog Tebchaws Meskas, Tebchaws Askiv, Tebchaws Europe, Russia, Israel, kuv lub tebchaws Taiwan thiab Hong Kong, tau txwv kev nkag mus ntawm cov neeg taug kev los ntawm sab qab teb Africa.
7. Kuv lub teb chaws cov lus teb ntsuas Peb lub teb chaws txoj kev tiv thaiv thiab kev tswj hwm lub tswv yim ntawm "kev tiv thaiv sab nraud, kev tiv thaiv sab hauv rov qab" tseem muaj txiaj ntsig rau Omi Keron mutant. Lub koom haum ntawm Viral Kab Mob ntawm Tuam Tshoj Center for Disease Control and Prevention tau tsim ib txoj kev tshawb nrhiav nucleic acid rau Omi Keron mutant strain, thiab txuas ntxiv ua cov kab mob genome soj ntsuam rau cov neeg tuaj txawv teb chaws tuaj. Cov kev ntsuas uas tau hais los saum toj no yuav pab txhawm rau txhawm rau tshawb xyuas lub sijhawm ntawm Omi Keron mutants uas tuaj yeem raug xa mus rau hauv kuv lub tebchaws.
8. WHO cov lus pom zoo rau cov lus teb rau Omi Keron mutant strains WHO pom zoo kom cov teb chaws ntxiv dag zog rau kev soj ntsuam, tshaj tawm thiab tshawb fawb txog tus kabmob tshiab no, thiab siv cov kev ntsuas kev noj qab haus huv rau pej xeem kom tsis txhob kis tus kabmob; Kev tiv thaiv kab mob zoo tau pom zoo rau cov tib neeg suav nrog ua kom nyob deb tsawg kawg yog 1 meter hauv cov chaw pej xeem, hnav lub qhov ncauj qhov ntswg, qhib qhov rais kom ua pa, thiab ua kom huv si, hnoos lossis txham rau hauv koj lub luj tshib lossis cov ntaub so ntswg, txhaj tshuaj tiv thaiv, thiab lwm yam, thiab tsis txhob mus rau qhov chaw uas muaj cua tsis zoo lossis muaj neeg coob coob. Piv nrog rau lwm yam VOC variants, nws tseem tsis paub meej tias Omi Keron variant muaj kev sib kis tau zoo dua, muaj kab mob thiab muaj peev xwm tiv thaiv kab mob. Cov kev tshawb fawb cuam tshuam yuav tau txais cov txiaj ntsig ua ntej hauv ob peb lub lis piam tom ntej. Tab sis qhov paub tam sim no yog tias txhua hom kab mob sib kis tuaj yeem ua rau muaj mob hnyav lossis tuag taus, yog li kev tiv thaiv kev kis tus kabmob yog qhov tseem ceeb, thiab cov tshuaj tiv thaiv kab mob tshiab tseem muaj txiaj ntsig los txo cov mob hnyav thiab tuag.
9. Nyob rau hauv lub ntsej muag ntawm qhov hloov pauv tshiab ntawm tus kabmob tshiab Omi Keron, cov pej xeem yuav tsum xyuam xim rau lawv txoj haujlwm thiab kev ua haujlwm txhua hnub? (1) Kev hnav lub npog ntsej muag tseem yog ib txoj hauv kev zoo los thaiv kev kis tus kabmob, thiab nws kuj tseem siv tau rau Omi Keron mutant hom. Txawm hais tias tag nrho cov kev txhaj tshuaj tiv thaiv thiab tshuaj tiv thaiv kab mob tau ua tiav lawm, nws tseem yuav tsum tau hnav lub npog ntsej muag hauv cov chaw pej xeem sab hauv, kev thauj mus los rau pej xeem thiab lwm qhov chaw. Tsis tas li ntawd, ntxuav koj txhais tes tsis tu ncua thiab ua kom cua nkag hauv chav. (2) Ua haujlwm zoo ntawm kev saib xyuas tus kheej. Thaum muaj cov tsos mob ntawm kev xav tias mob ntsws tshiab, xws li ua npaws, hnoos, ua tsis taus pa thiab lwm yam tsos mob, saib xyuas lub cev kub thiab pib mus ntsib kws kho mob. (3) Txo qhov tsis tsim nyog nkag thiab tawm. Tsuas yog ob peb hnub, ntau lub teb chaws thiab cheeb tsam tau tshaj tawm cov ntshuam ntawm Omi Keron mutant hom. Tuam Tshoj tseem ntsib txoj kev pheej hmoo ntawm kev xa tawm cov kab mob sib kis no, thiab kev paub thoob ntiaj teb tam sim no ntawm tus kab mob mutant no tseem txwv. Yog li ntawd, kev mus rau qhov chaw muaj kev pheej hmoo siab yuav tsum tau txo qis, thiab kev tiv thaiv tus kheej thaum mus ncig yuav tsum tau ntxiv dag zog kom txo tau txoj kev kis kab mob Omi Keron mutant hom.
Post lub sij hawm: Dec-17-2021